Product Name :
GC 14
Description:
GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
CAS:
447415-34-1
Molecular Weight:
449.50
Formula:
C26H27NO6
Chemical Name:
2-(4-{[6-hydroxy-4′-nitro-5-(propan-2-yl)-[1,1′-biphenyl]-3-yl]methyl}-3,5-dimethylphenoxy)acetic acid
Smiles :
CC1C=C(C=C(C)C=1CC1C=C(C(C)C)C(O)=C(C=1)C1C=CC(=CC=1)[N+]([O-])=O)OCC(O)=O
InChiKey:
PBZAEAFSLYJVGD-UHFFFAOYSA-N
InChi :
InChI=1S/C26H27NO6/c1-15(2)22-11-18(12-23-16(3)9-21(10-17(23)4)33-14-25(28)29)13-24(26(22)30)19-5-7-20(8-6-19)27(31)32/h5-11,13,15,30H,12,14H2,1-4H3,(H,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Gemcitabine} web|{Gemcitabine} Cell Cycle/DNA Damage|{Gemcitabine} Technical Information|{Gemcitabine} In stock|{Gemcitabine} custom synthesis|{Gemcitabine} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Neuromedin B} medchemexpress|{Neuromedin B} Metabolic Enzyme/Protease|{Neuromedin B} Purity & Documentation|{Neuromedin B} Description|{Neuromedin B} manufacturer|{Neuromedin B} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24518703
Additional information:
GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.|Product information|CAS Number: 447415-34-1|Molecular Weight: 449.50|Formula: C26H27NO6|Chemical Name: 2-(4-{[6-hydroxy-4′-nitro-5-(propan-2-yl)-[1,1′-biphenyl]-3-yl]methyl}-3,5-dimethylphenoxy)acetic acid|Smiles: CC1C=C(C=C(C)C=1CC1C=C(C(C)C)C(O)=C(C=1)C1C=CC(=CC=1)[N+]([O-])=O)OCC(O)=O|InChiKey: PBZAEAFSLYJVGD-UHFFFAOYSA-N|InChi: InChI=1S/C26H27NO6/c1-15(2)22-11-18(12-23-16(3)9-21(10-17(23)4)33-14-25(28)29)13-24(26(22)30)19-5-7-20(8-6-19)27(31)32/h5-11,13,15,30H,12,14H2,1-4H3,(H,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions.|References:|Koehler K, et al. Thyroid receptor ligands. 6. A high affinity “direct antagonist” selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7.Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5′-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46.Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20.Products are for research use only. Not for human use.|