Product Name :
SHR902275
Description:
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC50s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively.
CAS:
2695506-82-0
Molecular Weight:
512.48
Formula:
C26H23F3N4O4
Chemical Name:
Smiles :
CC1=CC=C(C=C1C1=CC2OC3(CC(=O)NC=2C=C1)CCOCC3)NC(=O)C1=CC(=CN=N1)C(F)(F)F
InChiKey:
LRTINOCIDJSJPY-UHFFFAOYSA-N
InChi :
InChI=1S/C26H23F3N4O4/c1-15-2-4-18(31-24(35)21-11-17(14-30-33-21)26(27,28)29)12-19(15)16-3-5-20-22(10-16)37-25(13-23(34)32-20)6-8-36-9-7-25/h2-5,10-12,14H,6-9,13H2,1H3,(H,31,35)(H,32,34)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{GCN2 modulator-1} MedChemExpress|{GCN2 modulator-1} Eukaryotic Initiation Factor (eIF)|{GCN2 modulator-1} Biological Activity|{GCN2 modulator-1} Formula|{GCN2 modulator-1} manufacturer|{GCN2 modulator-1} Epigenetic Reader Domain}
Additional information:
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers.{{Glycocholic acid} MedChemExpress|{Glycocholic acid} Metabolic Enzyme/Protease|{Glycocholic acid} Purity & Documentation|{Glycocholic acid} Description|{Glycocholic acid} supplier|{Glycocholic acid} Autophagy} SHR902275 has IC50s of 1.PMID:23910527 6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively.|Product information|CAS Number: 2695506-82-0|Molecular Weight: 512.48|Formula: C26H23F3N4O4|Smiles: CC1=CC=C(C=C1C1=CC2OC3(CC(=O)NC=2C=C1)CCOCC3)NC(=O)C1=CC(=CN=N1)C(F)(F)F|InChiKey: LRTINOCIDJSJPY-UHFFFAOYSA-N|InChi: InChI=1S/C26H23F3N4O4/c1-15-2-4-18(31-24(35)21-11-17(14-30-33-21)26(27,28)29)12-19(15)16-3-5-20-22(10-16)37-25(13-23(34)32-20)6-8-36-9-7-25/h2-5,10-12,14H,6-9,13H2,1H3,(H,31,35)(H,32,34)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040.Products are for research use only. Not for human use.|