Product Name :
Estrone sulfate sodium
Description:
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer.
CAS:
438-67-5
Molecular Weight:
372.41
Formula:
C18H21NaO5S
Chemical Name:
sodium (3aS, 3bR, 9bS, 11aS)-11a-methyl-1-oxo-1H, 2H, 3H, 3aH, 3bH, 4H, 5H, 9bH, 10H, 11H, 11aH-cyclopenta[a]phenanthren-7-yl sulfate
Smiles :
[Na+].C[C@]12CC[C@H]3[C@@H](CCC4=CC(=CC=C43)OS([O-])(=O)=O)[C@@H]1CCC2=O
InChiKey:
VUCAHVBMSFIGAI-ZFINNJDLSA-M
InChi :
InChI=1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,18+;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS).{{Olverembatinib} medchemexpress|{Olverembatinib} Protein Tyrosine Kinase/RTK|{Olverembatinib} Protocol|{Olverembatinib} Description|{Olverembatinib} manufacturer|{Olverembatinib} Epigenetic Reader Domain} strone sulfate can be used for the research of breast cancer.|Product information|CAS Number: 438-67-5|Molecular Weight: 372.41|Formula: C18H21NaO5S|Chemical Name: sodium (3aS, 3bR, 9bS, 11aS)-11a-methyl-1-oxo-1H, 2H, 3H, 3aH, 3bH, 4H, 5H, 9bH, 10H, 11H, 11aH-cyclopenta[a]phenanthren-7-yl sulfate|Smiles: [Na+].{{Dexrazoxane} web|{Dexrazoxane} Protocol|{Dexrazoxane} In stock|{Dexrazoxane} supplier|{Dexrazoxane} Autophagy} C[C@]12CC[C@H]3[C@@H](CCC4=CC(=CC=C43)OS([O-])(=O)=O)[C@@H]1CCC2=O|InChiKey: VUCAHVBMSFIGAI-ZFINNJDLSA-M|InChi: InChI=1S/C18H22O5S.PMID:24282960 Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,18+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|T47D cells are stably transfected with SOAT and incubated under increasing concentrations of Estrone sulfate and estradiol at physiologically relevant concentrations. Cell proliferation is significantly increased by 1 nM estradiol as well as by Estrone sulfate with EC50 of 2.2 nM.|References:|Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303.Products are for research use only. Not for human use.|