Product Name :
ERDRP-0519
Description:
ERDRP-0519 is an orally available polymerase inhibitor. It shows efficacy against a lethal morbillivirus infection in a large animal model. ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..
CAS:
1374006-96-8
Molecular Weight:
529.58
Formula:
C23H30F3N5O4S
Chemical Name:
1-methyl-N-(4-{[(2S)-2-[2-(morpholin-4-yl)ethyl]piperidin-1-yl]sulfonyl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Smiles :
CN1N=C(C=C1C(=O)NC1C=CC(=CC=1)S(=O)(=O)N1CCCC[C@H]1CCN1CCOCC1)C(F)(F)F
InChiKey:
JVZHTUQIMBYDSX-SFHVURJKSA-N
InChi :
InChI=1S/C23H30F3N5O4S/c1-29-20(16-21(28-29)23(24,25)26)22(32)27-17-5-7-19(8-6-17)36(33,34)31-10-3-2-4-18(31)9-11-30-12-14-35-15-13-30/h5-8,16,18H,2-4,9-15H2,1H3,(H,27,32)/t18-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ERDRP-0519 is an orally available polymerase inhibitor. It shows efficacy against a lethal morbillivirus infection in a large animal model. ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..|Product information|CAS Number: 1374006-96-8|Molecular Weight: 529.58|Formula: C23H30F3N5O4S|Chemical Name: 1-methyl-N-(4-{[(2S)-2-[2-(morpholin-4-yl)ethyl]piperidin-1-yl]sulfonyl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide|Smiles: CN1N=C(C=C1C(=O)NC1C=CC(=CC=1)S(=O)(=O)N1CCCC[C@H]1CCN1CCOCC1)C(F)(F)F|InChiKey: JVZHTUQIMBYDSX-SFHVURJKSA-N|InChi: InChI=1S/C23H30F3N5O4S/c1-29-20(16-21(28-29)23(24,25)26)22(32)27-17-5-7-19(8-6-17)36(33,34)31-10-3-2-4-18(31)9-11-30-12-14-35-15-13-30/h5-8,16,18H,2-4,9-15H2,1H3,(H,27,32)/t18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Triheptanoin} MedChemExpress|{Triheptanoin} Protocol|{Triheptanoin} References|{Triheptanoin} custom synthesis|{Triheptanoin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Pemafibrate} web|{Pemafibrate} Cell Cycle/DNA Damage|{Pemafibrate} Purity & Documentation|{Pemafibrate} Purity|{Pemafibrate} manufacturer|{Pemafibrate} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.PMID:35954127 07- 0.3 µM. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV).|In Vivo:|A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50 mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2 h post-administration (Cmax=3.27 µM).|References:|Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517. PubMed PMID: 24739760; PubMed Central PMCID: PMC4080709.Wittwer K, et al. Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding. Nat Commun. 2021 Sep 2;12(1):5233.Products are for research use only. Not for human use.|