Product Name :
6-Bnz-cAMP sodium salt
Description:
6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. Like PKA contains an evolutionally conserved cAMP-binding domain that acts as a molecular switch for sensing intracellular second messenger cAMP levels to control diverse biological functions. CAMP response element-binding protein (CREB) is the well-known direct target protein of PKA. Phosphorylation of CREB (pCREB) by PKA has been shown to be involved in regulating osteoblast differentiation. The proliferative signaling pathway which activated by the 6-Bnz-cAMP involves activation of the epidermal growth factor receptor and ERK1/2. Extending the duration of PKA-dependent ERK1/2 activation and converted cAMP from a proliferative into an anti-proliferative, neurite outgrowth- promoting signal. 6-Bnz-cAMP can promote not only differentiation and mineralization, but also initial cell adhesion.6-Bnz-cAMP is able to induce osteogenic differentiation of MC3T3-E1 cells. Moreover 6-Bnz-cAMP may facilitate release kinetic from a tissue-engineered polymeric scaffold system. It also can serve as a novel bone-inducing growth factor for repairing and regenerating bone tissues during bone regenerative engineering.
CAS:
1135306-29-4
Molecular Weight:
455.29
Formula:
C17H15N5NaO7P
Chemical Name:
N-{9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxo-2-(sodiooxy)-hexahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-9H-purin-6-yl}benzamide
Smiles :
O[C@H]1[C@@H](O[C@@H]2COP(=O)(O[Na])O[C@H]21)N1C=NC2C(NC(=O)C3C=CC=CC=3)=NC=NC1=2
InChiKey:
SPYGSKQRPXISIB-FKVBDRBCSA-M
InChi :
InChI=1S/C17H16N5O7P.Na/c23-12-13-10(6-27-30(25,26)29-13)28-17(12)22-8-20-11-14(18-7-19-15(11)22)21-16(24)9-4-2-1-3-5-9;/h1-5,7-8,10,12-13,17,23H,6H2,(H,25,26)(H,18,19,21,24);/q;+1/p-1/t10-,12-,13-,17-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. Like PKA contains an evolutionally conserved cAMP-binding domain that acts as a molecular switch for sensing intracellular second messenger cAMP levels to control diverse biological functions. CAMP response element-binding protein (CREB) is the well-known direct target protein of PKA. Phosphorylation of CREB (pCREB) by PKA has been shown to be involved in regulating osteoblast differentiation. The proliferative signaling pathway which activated by the 6-Bnz-cAMP involves activation of the epidermal growth factor receptor and ERK1/2. Extending the duration of PKA-dependent ERK1/2 activation and converted cAMP from a proliferative into an anti-proliferative, neurite outgrowth- promoting signal. 6-Bnz-cAMP can promote not only differentiation and mineralization, but also initial cell adhesion.6-Bnz-cAMP is able to induce osteogenic differentiation of MC3T3-E1 cells. Moreover 6-Bnz-cAMP may facilitate release kinetic from a tissue-engineered polymeric scaffold system.{{Ketoconazole} web|{Ketoconazole} Anti-infection|{Ketoconazole} Biological Activity|{Ketoconazole} In Vitro|{Ketoconazole} manufacturer|{Ketoconazole} Autophagy} It also can serve as a novel bone-inducing growth factor for repairing and regenerating bone tissues during bone regenerative engineering.{{Zalcitabine} site|{Zalcitabine} Reverse Transcriptase|{Zalcitabine} Biological Activity|{Zalcitabine} In Vitro|{Zalcitabine} supplier|{Zalcitabine} Autophagy} |Product information|CAS Number: 1135306-29-4|Molecular Weight: 455.PMID:25023702 29|Formula: C17H15N5NaO7P|Chemical Name: N-{9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxo-2-(sodiooxy)-hexahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-9H-purin-6-yl}benzamide|Smiles: O[C@H]1[C@@H](O[C@@H]2COP(=O)(O[Na])O[C@H]21)N1C=NC2C(NC(=O)C3C=CC=CC=3)=NC=NC1=2|InChiKey: SPYGSKQRPXISIB-FKVBDRBCSA-M|InChi: InChI=1S/C17H16N5O7P.Na/c23-12-13-10(6-27-30(25,26)29-13)28-17(12)22-8-20-11-14(18-7-19-15(11)22)21-16(24)9-4-2-1-3-5-9;/h1-5,7-8,10,12-13,17,23H,6H2,(H,25,26)(H,18,19,21,24);/q;+1/p-1/t10-,12-,13-,17-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|