S 70: 5942952. Ricca, A, Biroccio, A, Del Bufalo, D, Mackay, AR, Santoni, A and Cippitelli, M (2000). bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cells. Int J Cancer 86: 18896. Wick, W, Wagner, S, Kerkau, S, Dichgans, J, Tonn, JC and Weller, M (1998). BCL-2 promotes migration and invasiveness of human glioma cells. FEBS Lett 440: 41924. Takaoka, A, Adachi, M, Okuda, H, Sato, S, Yawata, A, Hinoda, Y et al. (1997). Anti-cell death activity promotes pulmonary metastasis of melanoma cells. Oncogene 14: 2971977. Reed, JC (1995). Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am 9: 45173. Fern dez, Y, Gu, B, Mart ez, A, Torregrosa, A and Sierra, A (2002). Inhibition of apial optosis in human breast cancer cells: role in tumor progression towards the metastatic state. Int J Cancer 101: 31726. Ozpolat, B, Sood, AK and Lopez-Berestein, G (2010). Nanomedicine primarily based approaches for the delivery of siRNA in cancer. J Intern Med 267: 443. Dorsett, Y and Tuschl, T (2004). siRNAs: applications in functional genomics and prospective as therapeutics. Nat Rev Drug Discov three: 31829. Rubinsztein, DC, Gestwicki, JE, Murphy, LO and Klionsky, DJ (2007). Prospective therapeutic applications of autophagy. Nat Rev Drug Discov six: 30412. Sonoke, S, Ueda, T, Fujiwara, K, Sato, Y, Takagaki, K, Hirabayashi, K et al. (2008). Tumor regression in mice by delivery of Bcl-2 compact interfering RNA with pegylated cationic liposomes. Cancer Res 68: 8843851. Tekedereli I, Akar U Lopez-Berestein G and Ozpolat B (2012). Therapeutic silencing of nanoliposomal EF2K by siRNA in principal and metastic breast cancer in animal models. PLoS A single 7(7): e41171.Molecular Therapy–Nucleic AcidsBcl-2 Silencing by siRNA Inhibits Breast Cancer Tumors Tekedereli et al.37. Lv, H, Zhang, S, Wang, B, Cui, S and Yan, J (2006). Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 114: 10009. 38. Kondo, Y, Kanzawa, T, Sawaya, R and Kondo, S (2005). The part of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 72634. 39. Hannon, GJ and Rossi, JJ (2004). Unlocking the potential on the human genome with RNA interference.Cidofovir Nature 431: 37178.Baclofen 40. Devarajan, E, Sahin, AA, Chen, JS, Krishnamurthy, RR, Aggarwal, N, Brun, AM et al. (2002). Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance.PMID:23756629 Oncogene 21: 8843851. 41. Moretti, L, Attia, A, Kim, KW and Lu, B (2007). Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy. Autophagy three(two): 14244. 42. van Nimwegen, MJ, Huigsloot, M, Camier, A, Tijdens, IB and van de Water, B (2006). Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. Mol Pharmacol 70: 1330339. 43. Bouchard, V, Harnois, C, Demers, MJ, Thibodeau, S, Laquerre, V, Gauthier, R et al. (2008). B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis 13: 53142. 44. Lee, BH and Ruoslahti, E (2005). alpha5beta1 integrin stimulates Bcl-2 expression and cell survival by means of Akt, focal adhesion kinase, and Ca2+/calmodulin-dependent protein kinase IV. J Cell Biochem 95: 1214223. 45. Nishimura, R, Osako, T, Okumura, Y, Hayashi, M, Toyozumi, Y and Arima, N (2010). Ki-67 as a prognostic marker in accordance with breast cancer subtype along with a predictor of recurrence.