Presented having a lesion around the left nasal alar skin that had slowly created over a fiveyear period. A biopsy was obtained as well as the lesion was histologically diagnosed as cutaneous squamous cell carcinoma (SCC). A nasopharyngeal neoplasm was also Complement System Purity & Documentation detected by 18fluorine2fluoro2deoxyd-glucose positron emission tomography/computed tomography and nasopharyngoscopy. A biopsy in the nasopharyngeal neoplasm confirmed a diagnosis of SCC. On the other hand, a tiny EBV-encoded nuclear RNA (EBER) test demonstrated that the nasopharyngeal tumor cells have been all damaging for EBV. Because the majority of nasopharyngeal carcinomas have been constructive for EBER, it was concluded that the nasopharyngeal carcinoma had metastasized from the cutaneous SCC. A brief overview of literature can also be presented, as well as a discussion of the pathogen, epidemiology and diagnosis of cutaneous and nasopharyngeal carcinomas. Introduction Non-melanoma cutaneous cancer may be the most common form of malignancy occurring worldwide and consists mostly of basal cell carcinoma and squamous cell carcinoma (SCC) (1). Its occurrence is connected with light exposure, the presence of scars, ethnicity along with other factors. Nasopharyngeal carcinoma is one of the most frequent types of malignancy in Southern China and is closely connected with Epstein-Barr virus (EBV) infection (two). The present report presents a case of left nasal alar cutaneous SCC and nasopharyngeal SCC diagnosed concurrently. Depending on evaluation of histology, epidemiology and etiology from the tumors at the two internet sites, it was concluded that cutaneous SCC was the key carcinoma and that it had metastasized towards the nasopharynx. A brief literature overview can also be integrated on the pathogenesis, epidemiology and diagnosis of cutaneous SCC and nasopharyngeal carcinoma. The PD-1/PD-L1 Modulator Species patient offered written informed consent for the publication of this study. Case report A 53-year-old female presented having a scar that was accompanied by erosion of the left nasal alar skin. The lesion was 2.five cm in diameter and had originally created as a papule, which was 0.three cm in diameter, five years previously. The patient scratched the papule resulting from pruritus, which resulted in breakage, and repeatedly scratched the web page when the breakage had healed, causing a scar to at some point type. The scar slowly grew through the repeated process of breakage and healing until the patient was admitted to Sichuan Provincial People’s Hospital (Chengdu, China) in November of 2011. The patient consented to wholebody 18fluorine2fluoro2deoxyd-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) examination, plus the results revealed 18F-FDG uptake inside the left nasal alar skin and also the appropriate wall of your nasopharynx. Moreover, quite a few cervical and parapharyngeal lymph nodes demonstrated 18F-FDG uptake (Figs. 1 and 2). The left nasal alar lesion was removed surgically with clear margins, and histological benefits confirmed that the lesion was cutaneous SCC with keratosis. Examination using a nasopharyngoscope was performed, which revealed a neoplasm on the ideal wall of the nasopharynx. A biopsy from the neoplasm was conducted, and also the pathology final results confirmed that the neoplasm was SCC with keratosis. EBV-encoded RNA (EBER) was performed in situ inside the nasopharyngeal SCC lesion. The nasopharyngeal tumorCorrespondence to: Dr Rui Ao, Department of Oncology, SichuanAcademy of Medical Sciences, Sichuan Provincial People’s Hospital, 32 West Second Section Initial Ring.