Ficant drop in activity versus the Y188L mutant (13 ?0.5 nM). TheFicant drop in activity
Ficant drop in activity versus the Y188L mutant (13 ?0.5 nM). TheFicant drop in activity versus the Y188L mutant (13 ?0.5 nM). The `flipped' analogue (Figure 2, analogue 13) maintained…