Met the MK-5172 chemical Quisinostat web information CLIF-C definition and both definitions had more organ failure, such as kidney, cerebral, coagulation, circulation and lung failure, than patients who only met the AARC definition. In contrast, hepatic failure was more frequent in the AARC only group. In terms of clinical scoring systems, MELD, MELD-Na and CLIF-SOFA scores were higher in the CLIF-C only group than in the AARC only group.Mortality according to fnins.2015.00094 the definition of underlying CLD (confinement to liver cirrhosis only vs. encompassing liver cirrhosis and other CLD)We investigated whether the presence of non-cirrhotic CLD influenced mortality in total enrolled patients with acute deterioration. Because the CLIF-C defines ACLF only in those patients with liver cirrhosis, we analyzed mortality WP1066MedChemExpress WP1066 difference according to the presence of ACLF as defined by the AARC (Fig 6). Among patients with liver cirrhosis, the EPZ-5676 biological activity 28-day and 90-day mortalities of patients with ACLF were higher than those without ACLF (28-day mortality: 27.0 vs. 5.8 , P < 0.001; 90-day mortality: 42.6 vs. 10.7 , P < 0.001). Among patients without liver cirrhosis, the 90-day mortality of patients with ACLF was, although not significant, higher than thosePLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,9 /Acute-on-Chronic Liver FailureTable 2. Discordant baseline characteristics between patients with ACLF defined by the AARC or CLIF-C. Characteristics (N = 340) Age (y) Male sex Cause of CLD HBV HCV Alcohol HBV+alcohol HCV+alcohol Others Acute Decompensation Ascites Hepatic encephalopathy GI Bleeding Infection More than one event Precipitating events Bacterial infection GI Bleeding Active alcoholism Toxic material Reactivation of viral infection Others SIRS Mean Blood Pressure (mmHg) Laboratory findings WBC (x109/uL) ANC (x109/uL) Hemoglobin (g/dL) Platelet count (x109/L) Albumin (g/dL) Bilirubin (mg/dL) ALT (U/L) AST (U/L) GGT (U/L) INR CRP (mg/L) Creatinine (mg/dL) Sodium (mEq/L) Clinical scores CTP score MELD score MELD-Na score CLIF-SOFA score Organ failure by CLIF-SOFA score Liver Kidney Cerebral 16 (24.2) 2 (3.0) 1 (1.5) 52 (26.0) 98 (49.0)* 35 (17.5)* 40 (54.1)*# 27 (36.5)* 17 (23.0)* <0.001 <0.001 0.001 (Continued) 11 ?1 21 ?4 23 ?5 6? 10 ?2 24 ?7* 27 ?7* 9 ?4* 11 ?2*# 28 ?8*# 31?7*# 10 ?4*# <0.001 <0.001 <0.001 <0.001 9.63 ?7.10 7.16 ?6.67 10.8 ?2.2 110 ?60 2.6 ?0.4 10.5 ?6.8 83 ?144 191 ?215 294 ?305 1.71 ?0.29 3.76 ?5.95 0.9 ?0.4 135 ?6 10.25 ?6.12 7.99 ?5.55 9.3 ?2.7* 91 ?54 2.6 ?0.6 8.1 ?9.1 65 ?121 164 ?373 165 ?237* 1.91 ?1.08 5.78 ?11.93 2.4 ?2.1* 133 ?8 11.88 ?5.95 9.43 ?5.31 10.0 ?2.6 105 ?68 2.5 ?0.6 15.0 ?8.7* 167 ?447# 578 ?2270# 293 ?365# 2.23 ?0.97* 4.69 ?6.40 2.3 ?3.3* 131 ?7* 0.079 0.056 <0.001 0.034 0.618 <0.001 0.007 0.019 <0.001 0.005 0.330 <0.001 0.006 5 (7.6) 5 (7.6) 43 (65.2) 3 (4.5) 3 (4.5) 2 (3.0) a0023781 16 (24.2) 94 ?15 37 (18.5)* 62 (31.0)* 82 (41.0)* 1 (0.5)* 5 (2.5) 10 (5.0) 65 (32.5) 83 ?19* 15 (20.3)* 13 (17.6)# 44 (59.5)# 2 (2.7) 5 (6.8) 1 (1.4) 28 (37.8) 83 ?22* 0.079 <0.001 0.001 0.076 0.249 0.351 0.223 <0.001 50 (75.8) 6 (9.1) 8 (12.1) 8 (12.1) 8 (12.1) 58 (29.0)* 63 (31.5)* 77 (38.5)* 42 (21.0) 42 (21.0) 44 (59.5)*# 29 (39.2)* 12 (16.2)# 16 (21.6) 21 (28.4)* <0.001 <0.001 <0.001 0.247 0.061 4 (6.1) 1 (1.5) 51 (77.3) 4 (6.1) 2 (3.0) 4 (6.1) 23 (11.5) 12 (6.0) 136 (68.0) 15 (7.5) 3 (1.5) 11 (5.5) 4 (5.4) 2 (2.7) 57 (77.0) 6 (8.1) 1 (1.4) 4 (5.4) AARC only (N = 66) 50 ?9 50 (75.8) CLIF-C only (N = 200) 56 ?11* 154 (77.0) Both Definitions (N = 74) 52 ?#P value <0.001 0.977.Met the CLIF-C definition and both definitions had more organ failure, such as kidney, cerebral, coagulation, circulation and lung failure, than patients who only met the AARC definition. In contrast, hepatic failure was more frequent in the AARC only group. In terms of clinical scoring systems, MELD, MELD-Na and CLIF-SOFA scores were higher in the CLIF-C only group than in the AARC only group.Mortality according to fnins.2015.00094 the definition of underlying CLD (confinement to liver cirrhosis only vs. encompassing liver cirrhosis and other CLD)We investigated whether the presence of non-cirrhotic CLD influenced mortality in total enrolled patients with acute deterioration. Because the CLIF-C defines ACLF only in those patients with liver cirrhosis, we analyzed mortality difference according to the presence of ACLF as defined by the AARC (Fig 6). Among patients with liver cirrhosis, the 28-day and 90-day mortalities of patients with ACLF were higher than those without ACLF (28-day mortality: 27.0 vs. 5.8 , P < 0.001; 90-day mortality: 42.6 vs. 10.7 , P < 0.001). Among patients without liver cirrhosis, the 90-day mortality of patients with ACLF was, although not significant, higher than thosePLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,9 /Acute-on-Chronic Liver FailureTable 2. Discordant baseline characteristics between patients with ACLF defined by the AARC or CLIF-C. Characteristics (N = 340) Age (y) Male sex Cause of CLD HBV HCV Alcohol HBV+alcohol HCV+alcohol Others Acute Decompensation Ascites Hepatic encephalopathy GI Bleeding Infection More than one event Precipitating events Bacterial infection GI Bleeding Active alcoholism Toxic material Reactivation of viral infection Others SIRS Mean Blood Pressure (mmHg) Laboratory findings WBC (x109/uL) ANC (x109/uL) Hemoglobin (g/dL) Platelet count (x109/L) Albumin (g/dL) Bilirubin (mg/dL) ALT (U/L) AST (U/L) GGT (U/L) INR CRP (mg/L) Creatinine (mg/dL) Sodium (mEq/L) Clinical scores CTP score MELD score MELD-Na score CLIF-SOFA score Organ failure by CLIF-SOFA score Liver Kidney Cerebral 16 (24.2) 2 (3.0) 1 (1.5) 52 (26.0) 98 (49.0)* 35 (17.5)* 40 (54.1)*# 27 (36.5)* 17 (23.0)* <0.001 <0.001 0.001 (Continued) 11 ?1 21 ?4 23 ?5 6? 10 ?2 24 ?7* 27 ?7* 9 ?4* 11 ?2*# 28 ?8*# 31?7*# 10 ?4*# <0.001 <0.001 <0.001 <0.001 9.63 ?7.10 7.16 ?6.67 10.8 ?2.2 110 ?60 2.6 ?0.4 10.5 ?6.8 83 ?144 191 ?215 294 ?305 1.71 ?0.29 3.76 ?5.95 0.9 ?0.4 135 ?6 10.25 ?6.12 7.99 ?5.55 9.3 ?2.7* 91 ?54 2.6 ?0.6 8.1 ?9.1 65 ?121 164 ?373 165 ?237* 1.91 ?1.08 5.78 ?11.93 2.4 ?2.1* 133 ?8 11.88 ?5.95 9.43 ?5.31 10.0 ?2.6 105 ?68 2.5 ?0.6 15.0 ?8.7* 167 ?447# 578 ?2270# 293 ?365# 2.23 ?0.97* 4.69 ?6.40 2.3 ?3.3* 131 ?7* 0.079 0.056 <0.001 0.034 0.618 <0.001 0.007 0.019 <0.001 0.005 0.330 <0.001 0.006 5 (7.6) 5 (7.6) 43 (65.2) 3 (4.5) 3 (4.5) 2 (3.0) a0023781 16 (24.2) 94 ?15 37 (18.5)* 62 (31.0)* 82 (41.0)* 1 (0.5)* 5 (2.5) 10 (5.0) 65 (32.5) 83 ?19* 15 (20.3)* 13 (17.6)# 44 (59.5)# 2 (2.7) 5 (6.8) 1 (1.4) 28 (37.8) 83 ?22* 0.079 <0.001 0.001 0.076 0.249 0.351 0.223 <0.001 50 (75.8) 6 (9.1) 8 (12.1) 8 (12.1) 8 (12.1) 58 (29.0)* 63 (31.5)* 77 (38.5)* 42 (21.0) 42 (21.0) 44 (59.5)*# 29 (39.2)* 12 (16.2)# 16 (21.6) 21 (28.4)* <0.001 <0.001 <0.001 0.247 0.061 4 (6.1) 1 (1.5) 51 (77.3) 4 (6.1) 2 (3.0) 4 (6.1) 23 (11.5) 12 (6.0) 136 (68.0) 15 (7.5) 3 (1.5) 11 (5.5) 4 (5.4) 2 (2.7) 57 (77.0) 6 (8.1) 1 (1.4) 4 (5.4) AARC only (N = 66) 50 ?9 50 (75.8) CLIF-C only (N = 200) 56 ?11* 154 (77.0) Both Definitions (N = 74) 52 ?#P value <0.001 0.977.Met the CLIF-C definition and both definitions had more organ failure, such as kidney, cerebral, coagulation, circulation and lung failure, than patients who only met the AARC definition. In contrast, hepatic failure was more frequent in the AARC only group. In terms of clinical scoring systems, MELD, MELD-Na and CLIF-SOFA scores were higher in the CLIF-C only group than in the AARC only group.Mortality according to fnins.2015.00094 the definition of underlying CLD (confinement to liver cirrhosis only vs. encompassing liver cirrhosis and other CLD)We investigated whether the presence of non-cirrhotic CLD influenced mortality in total enrolled patients with acute deterioration. Because the CLIF-C defines ACLF only in those patients with liver cirrhosis, we analyzed mortality difference according to the presence of ACLF as defined by the AARC (Fig 6). Among patients with liver cirrhosis, the 28-day and 90-day mortalities of patients with ACLF were higher than those without ACLF (28-day mortality: 27.0 vs. 5.8 , P < 0.001; 90-day mortality: 42.6 vs. 10.7 , P < 0.001). Among patients without liver cirrhosis, the 90-day mortality of patients with ACLF was, although not significant, higher than thosePLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,9 /Acute-on-Chronic Liver FailureTable 2. Discordant baseline characteristics between patients with ACLF defined by the AARC or CLIF-C. Characteristics (N = 340) Age (y) Male sex Cause of CLD HBV HCV Alcohol HBV+alcohol HCV+alcohol Others Acute Decompensation Ascites Hepatic encephalopathy GI Bleeding Infection More than one event Precipitating events Bacterial infection GI Bleeding Active alcoholism Toxic material Reactivation of viral infection Others SIRS Mean Blood Pressure (mmHg) Laboratory findings WBC (x109/uL) ANC (x109/uL) Hemoglobin (g/dL) Platelet count (x109/L) Albumin (g/dL) Bilirubin (mg/dL) ALT (U/L) AST (U/L) GGT (U/L) INR CRP (mg/L) Creatinine (mg/dL) Sodium (mEq/L) Clinical scores CTP score MELD score MELD-Na score CLIF-SOFA score Organ failure by CLIF-SOFA score Liver Kidney Cerebral 16 (24.2) 2 (3.0) 1 (1.5) 52 (26.0) 98 (49.0)* 35 (17.5)* 40 (54.1)*# 27 (36.5)* 17 (23.0)* <0.001 <0.001 0.001 (Continued) 11 ?1 21 ?4 23 ?5 6? 10 ?2 24 ?7* 27 ?7* 9 ?4* 11 ?2*# 28 ?8*# 31?7*# 10 ?4*# <0.001 <0.001 <0.001 <0.001 9.63 ?7.10 7.16 ?6.67 10.8 ?2.2 110 ?60 2.6 ?0.4 10.5 ?6.8 83 ?144 191 ?215 294 ?305 1.71 ?0.29 3.76 ?5.95 0.9 ?0.4 135 ?6 10.25 ?6.12 7.99 ?5.55 9.3 ?2.7* 91 ?54 2.6 ?0.6 8.1 ?9.1 65 ?121 164 ?373 165 ?237* 1.91 ?1.08 5.78 ?11.93 2.4 ?2.1* 133 ?8 11.88 ?5.95 9.43 ?5.31 10.0 ?2.6 105 ?68 2.5 ?0.6 15.0 ?8.7* 167 ?447# 578 ?2270# 293 ?365# 2.23 ?0.97* 4.69 ?6.40 2.3 ?3.3* 131 ?7* 0.079 0.056 <0.001 0.034 0.618 <0.001 0.007 0.019 <0.001 0.005 0.330 <0.001 0.006 5 (7.6) 5 (7.6) 43 (65.2) 3 (4.5) 3 (4.5) 2 (3.0) a0023781 16 (24.2) 94 ?15 37 (18.5)* 62 (31.0)* 82 (41.0)* 1 (0.5)* 5 (2.5) 10 (5.0) 65 (32.5) 83 ?19* 15 (20.3)* 13 (17.6)# 44 (59.5)# 2 (2.7) 5 (6.8) 1 (1.4) 28 (37.8) 83 ?22* 0.079 <0.001 0.001 0.076 0.249 0.351 0.223 <0.001 50 (75.8) 6 (9.1) 8 (12.1) 8 (12.1) 8 (12.1) 58 (29.0)* 63 (31.5)* 77 (38.5)* 42 (21.0) 42 (21.0) 44 (59.5)*# 29 (39.2)* 12 (16.2)# 16 (21.6) 21 (28.4)* <0.001 <0.001 <0.001 0.247 0.061 4 (6.1) 1 (1.5) 51 (77.3) 4 (6.1) 2 (3.0) 4 (6.1) 23 (11.5) 12 (6.0) 136 (68.0) 15 (7.5) 3 (1.5) 11 (5.5) 4 (5.4) 2 (2.7) 57 (77.0) 6 (8.1) 1 (1.4) 4 (5.4) AARC only (N = 66) 50 ?9 50 (75.8) CLIF-C only (N = 200) 56 ?11* 154 (77.0) Both Definitions (N = 74) 52 ?#P value <0.001 0.977.Met the CLIF-C definition and both definitions had more organ failure, such as kidney, cerebral, coagulation, circulation and lung failure, than patients who only met the AARC definition. In contrast, hepatic failure was more frequent in the AARC only group. In terms of clinical scoring systems, MELD, MELD-Na and CLIF-SOFA scores were higher in the CLIF-C only group than in the AARC only group.Mortality according to fnins.2015.00094 the definition of underlying CLD (confinement to liver cirrhosis only vs. encompassing liver cirrhosis and other CLD)We investigated whether the presence of non-cirrhotic CLD influenced mortality in total enrolled patients with acute deterioration. Because the CLIF-C defines ACLF only in those patients with liver cirrhosis, we analyzed mortality difference according to the presence of ACLF as defined by the AARC (Fig 6). Among patients with liver cirrhosis, the 28-day and 90-day mortalities of patients with ACLF were higher than those without ACLF (28-day mortality: 27.0 vs. 5.8 , P < 0.001; 90-day mortality: 42.6 vs. 10.7 , P < 0.001). Among patients without liver cirrhosis, the 90-day mortality of patients with ACLF was, although not significant, higher than thosePLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,9 /Acute-on-Chronic Liver FailureTable 2. Discordant baseline characteristics between patients with ACLF defined by the AARC or CLIF-C. Characteristics (N = 340) Age (y) Male sex Cause of CLD HBV HCV Alcohol HBV+alcohol HCV+alcohol Others Acute Decompensation Ascites Hepatic encephalopathy GI Bleeding Infection More than one event Precipitating events Bacterial infection GI Bleeding Active alcoholism Toxic material Reactivation of viral infection Others SIRS Mean Blood Pressure (mmHg) Laboratory findings WBC (x109/uL) ANC (x109/uL) Hemoglobin (g/dL) Platelet count (x109/L) Albumin (g/dL) Bilirubin (mg/dL) ALT (U/L) AST (U/L) GGT (U/L) INR CRP (mg/L) Creatinine (mg/dL) Sodium (mEq/L) Clinical scores CTP score MELD score MELD-Na score CLIF-SOFA score Organ failure by CLIF-SOFA score Liver Kidney Cerebral 16 (24.2) 2 (3.0) 1 (1.5) 52 (26.0) 98 (49.0)* 35 (17.5)* 40 (54.1)*# 27 (36.5)* 17 (23.0)* <0.001 <0.001 0.001 (Continued) 11 ?1 21 ?4 23 ?5 6? 10 ?2 24 ?7* 27 ?7* 9 ?4* 11 ?2*# 28 ?8*# 31?7*# 10 ?4*# <0.001 <0.001 <0.001 <0.001 9.63 ?7.10 7.16 ?6.67 10.8 ?2.2 110 ?60 2.6 ?0.4 10.5 ?6.8 83 ?144 191 ?215 294 ?305 1.71 ?0.29 3.76 ?5.95 0.9 ?0.4 135 ?6 10.25 ?6.12 7.99 ?5.55 9.3 ?2.7* 91 ?54 2.6 ?0.6 8.1 ?9.1 65 ?121 164 ?373 165 ?237* 1.91 ?1.08 5.78 ?11.93 2.4 ?2.1* 133 ?8 11.88 ?5.95 9.43 ?5.31 10.0 ?2.6 105 ?68 2.5 ?0.6 15.0 ?8.7* 167 ?447# 578 ?2270# 293 ?365# 2.23 ?0.97* 4.69 ?6.40 2.3 ?3.3* 131 ?7* 0.079 0.056 <0.001 0.034 0.618 <0.001 0.007 0.019 <0.001 0.005 0.330 <0.001 0.006 5 (7.6) 5 (7.6) 43 (65.2) 3 (4.5) 3 (4.5) 2 (3.0) a0023781 16 (24.2) 94 ?15 37 (18.5)* 62 (31.0)* 82 (41.0)* 1 (0.5)* 5 (2.5) 10 (5.0) 65 (32.5) 83 ?19* 15 (20.3)* 13 (17.6)# 44 (59.5)# 2 (2.7) 5 (6.8) 1 (1.4) 28 (37.8) 83 ?22* 0.079 <0.001 0.001 0.076 0.249 0.351 0.223 <0.001 50 (75.8) 6 (9.1) 8 (12.1) 8 (12.1) 8 (12.1) 58 (29.0)* 63 (31.5)* 77 (38.5)* 42 (21.0) 42 (21.0) 44 (59.5)*# 29 (39.2)* 12 (16.2)# 16 (21.6) 21 (28.4)* <0.001 <0.001 <0.001 0.247 0.061 4 (6.1) 1 (1.5) 51 (77.3) 4 (6.1) 2 (3.0) 4 (6.1) 23 (11.5) 12 (6.0) 136 (68.0) 15 (7.5) 3 (1.5) 11 (5.5) 4 (5.4) 2 (2.7) 57 (77.0) 6 (8.1) 1 (1.4) 4 (5.4) AARC only (N = 66) 50 ?9 50 (75.8) CLIF-C only (N = 200) 56 ?11* 154 (77.0) Both Definitions (N = 74) 52 ?#P value <0.001 0.977.