Recombinant Rat EGF
EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-α and VGF (vaccinia virus growth factor). Recombinant rat EGF is a 6.2 kDa globular protein containing 54 amino acid residues including 3 intramolecular disulfide-bonds. LDE227 (Diphosphate)
|
Source: |
E. Coli
|
|   | |
|
Purity:
|
Above 98% as determined by SDS-PAGE Analysis.
|
|   | |
|
Cross Reactivity: |
Mouse
|
|   | |
|
Biological Activity
|
The ED50 was determined by a cell proliferation assay using BALB/c 3T3 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
|
|   | |
|
AA Sequence
|
MNSNTGCPP SYDGYCLNG GVCMYVESV DRYVCNCVI GYIGERCQH RDLRWWKLR
|
| Research Interest: | , , , , Inflammation, Proliferation and Cell Cycle |
| Protein Cross Reactivity: | Mouse |