Recombinant Murine PDGF-AA


PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Exatecan (Mesylate)


Source:
E. Coli
&nbsp

Purity:
Above 98% as determined by SDS-PAGE Analysis.
&nbsp

Cross Reactivity:
NULL
&nbsp

Biological Activity
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 8-10 ng/ml.
&nbsp

AA Sequence
MSIEEAVPA VCKTRTVIY EIPRSQVDP TSANFLIWP PCVEVKRCT GCCNTSSVK CQPSRVHHR SVKVAKVEY VRKKPKLKE VQVRLEEHL ECACATSNL NPDHREEET GRRRESGKN RKRKRLKPT
Research Interest: , , , , ,
Cell Type: , Neurons
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg

$80.00

10µg

$195.00

100µg

$780.00

500µg

$2,340.00

1mg

$3,900.00

MED: 190591

Recombinant Murine PDGF-AA


PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids). TG6-10-4


Source:
E. Coli
&nbsp

Purity:
Above 98% as determined by SDS-PAGE Analysis.
&nbsp

Cross Reactivity:
NULL
&nbsp

Biological Activity
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 8-10 ng/ml.
&nbsp

AA Sequence
MSIEEAVPA VCKTRTVIY EIPRSQVDP TSANFLIWP PCVEVKRCT GCCNTSSVK CQPSRVHHR SVKVAKVEY VRKKPKLKE VQVRLEEHL ECACATSNL NPDHREEET GRRRESGKN RKRKRLKPT
Research Interest: , , , , ,
Cell Type: , Neurons
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg

$80.00

10µg

$195.00

100µg

$780.00

500µg

$2,340.00

1mg

$3,900.00

MED: 19064739

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