Recombinant Human sTRAIL Receptor-1
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain, ” which can activate the cells apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain. 7-Fluorouracil
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 µg/ml.
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AA Sequence
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MSGTGAAAA TPSKVWGSS AGRIEPRGG GRGALPTSM GQHGPSARA RAGRAPGPR PAREASPRL RVHKTFKFV VVGVLLQVV PSSAATIKL HDQSIGTQQ WEHSPLGEL CPPGSHRSE RPGACNRCT EGVGYTNAS QQLFACLPC TACKSDEEE RSPCTTTRN TACQCKPGT FRNDNSAEM CRKCSTGCP RGMVKVKDC TPWSDIECV HKESGNGHN
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| Research Interest: | |
| Protein Cross Reactivity: | NULL |