Recombinant Human IGF-BP2
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc. GNE-620 (hydrochloride)
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Source: |
(BTI-Tn-5B1-4) Hi-5 Insect cells*
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
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AA Sequence
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EVLFRCPPC TPERLAACG PPPVAPPAA VAAVAGGAR MPCAELVRE PGCGCCSVC ARLEGEACQ VYTPRCGQG LRCYPHPGS ELPLQALVM GEGTCEKRR DAEYGASPE QVADNGDDH SEGGLVENH VDSTMNMLG GGGSAGRKP LKSGMKELA VFREKVTEQ HRQMGKGGK HHLGLEEPK KLRPPPART PCQQELDQV LERISTMRL PDERGPLEH LYSLHIPNC DKHGLYNLK QCKMSLNGQ RGECWCVNP NTGKLIQGA PTIRGDPEC HLFYNEQQE ARGVHTQRM Q
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| Research Interest: | , , , Proliferation and Cell Cycle, |
| Cell Type: | |
| Protein Cross Reactivity: | Mouse |