Recombinant Human BMP-2
BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. Exendin-6
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Cow, Dog, Monkey, Mouse, Rabbit, Rat
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Biological Activity
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Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
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AA Sequence
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MQAKHKQRK RLKSSCKRH PLYVDFSDV GWNDWIVAP PGYHAFYCH GECPFPLAD HLNSTNHAI VQTLVNSVN SKIPKACCV PTELSAISM LYLDENEKV VLKNYQDMV VEGCGCR
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| Research Interest: | , , , Proliferation and Cell Cycle |
| Protein Cross Reactivity: | Cow, Dog, Monkey, Mouse, Rabbit, Rat |