Recombinant Human BMP-13/CDMP-2
BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. Cabozantinib
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Source: |
E. Coli
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Purity:
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Above 95% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml.
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AA Sequence
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TAFASRHGK RHGKKSRLR CSKKPLHVN FKELGWDDW IIAPLEYEA YHCEGVCDF PLRSHLEPT NHAIIQTLM NSMDPGSTP PSCCVPTKL TPISILYID AGNNVVYKQ YEDMVVESC GCR
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| Research Interest: | , , , , Proliferation and Cell Cycle |
| Protein Cross Reactivity: | Mouse |