Anti-Rat CD28 SAFIRE Purified
The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2). AdipoRon
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Clone
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JJ319
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Rat
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Isotype:
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Mouse IgG1
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Tacke, M., Clark, G. J., Dallman, M. J., & Hünig, T. (1995). Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. The Journal of Immunology, 154(10), 5121-5127. Tacke, M., Hanke, G., Hanke, T., & Hünig, T. (1997). CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28. European journal of immunology, 27(1), 239-247. Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity, 2(6), 555-559.
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