Anti-Mouse TNF-Alpha APC
The MP6-XT22 monoclonal antibody specifically reacts with mouse tumor necrosis factor alpha (TNF-alpha), a 156 amino pro-inflammatory cytokine. It is secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. NF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MP6-XT22 is reported to neutralize the bioactivity of natural or recombinant TNF-alpha and is useful for intracellular immunofluorescent staining. Linsitinib
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Clone
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MP6-XT22
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Format: |
APC
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Rat IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Abrams, J. S. (1995). Immunoenzymetric assay of mouse and human cytokines using NIP‐labeled anti‐cytokine antibodies. Current Protocols in Immunology, 6-20. Williams, R. O., Mauri, C., Mason, L. J., Marinova‐Mutafchieva, L., Ross, S. E., Feldmann, M., & Maini, R. N. (1998). Therapeutic actions of cyclosporine and anti‐tumor necrosis factor α in collagen‐induced arthritis and the effect of combination therapy. Arthritis & Rheumatism, 41(10), 1806-1812. Litton, M. J., Remington, J. S., & Abrams, J. S. (1994). Immunocytochemical detection of cytokines in the lymph nodes and brains of mice resistant or susceptible to toxoplasmic encephalitis. Journal of Infectious Diseases, 170(4), 939-945. |