Anti-Mouse/Rat CD61 (Integrin beta 3) SAFIRE Purified
The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51. The complex binds to other ligands such as fibrinogen, fibronectin, thrombospondin, and von WIllebrand factor. It is expressed by granulocytes, platelets, activated T cells, smooth muscle, and a subset of B cells. Dabrafenib
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Clone
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2C9.G3
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Mouse, Rat
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Vaillant, F., Asselin-Labat, M. L., Shackleton, M., Forrest, N. C., Lindeman, G. J., & Visvader, J. E. (2008). The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.Cancer research, 68(19), 7711-7717. Yasuda, M., Hasunuma, Y., Adachi, H., Sekine, C., Sakanishi, T., Hashimoto, H., … & Okumura, K. (1995). Expression and function of fibronectin binding integrins on rat mast cells. International immunology, 7(2), 251-258. Wu, X., Mogford, J. E., Platts, S. H., Davis, G. E., Meininger, G. A., & Davis, M. J. (1998). Modulation of calcium current in arteriolar smooth muscle by αvβ3 and α5β1 integrin ligands. The Journal of cell biology, 143(1), 241-252. |