Anti-Mouse KLRG1 BG Violet 450
The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen). The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif). KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity.
The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.
|
Clone
|
2F1
|
|
Format: |
BG Violet 450
|
|
Applications
|
FC
|
|
Reactivity
|
Mouse
|
|
Isotype:
|
Golden Syrian Hamster IgG
|
| Research Interest: | , |
| Cell Type: | , |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Beyersdorf, N. B., Ding, X., Karp, K., & Hanke, T. (2001). Expression of inhibitory” killer cell lectin-like receptor G1″ identifies unique subpopulations of effector and memory CD8 T cells. European journal of immunology, 31(12), 3443-3452. Corral, L., Hanke, T., Vance, R. E., Cado, D., & Raulet, D. H. (2000). NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. European journal of immunology, 30(3), 920-930. Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T., & Brossay, L. (2003). Differential regulation of killer cell lectin-like receptor G1 expression on T cells. The Journal of Immunology, 170(12), 5876-5885. |