Anti-Mouse CD48 PE
The HM48-1 monoclonal antibody specifically reacts with mouse CD48, a GPI-anchored molecule in the Ig superfamily. CD48 was previously known as BCM1 in mice, Blast-1 in humans, and OX-45 in rats. Its ligands are CD2 and CD244 and it is expressed on leukocytes to the exclusion of non-hematopoietic cells. The utilization of the HM48-1 antibody has been reported to prolong cardiac allografts survival in in vivo studies. The antibody blocks the interaction of CD2 and CD244, inhibits CTL priming, and blocks the binding of soluble CD2 to CD48 expressing cells. SAR407
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Clone
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HM48-1
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Format: |
PE
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., … & Yagita, H. (1992). CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. The Journal of experimental medicine, 176(5), 1241-1249. Qin, L., Chavin, K. D., Lin, J., Yagita, H., & Bromberg, J. S. (1994). Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. The Journal of experimental medicine, 179(1), 341-346. Chavin, K. D., Qin, L., Lin, J., Woodward, J., Baliga, P., Kato, K., … & Bromberg, J. S. (1994). Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo. International immunology, 6(5), 701-709. |