Anti-Mouse CD252 (OX40L) Biotin
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L. LDE225 (Diphosphate)
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Clone
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RM134L
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Format: |
Biotin
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Rat IgG2b, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted biotin was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Stüber, E., Neurath, M., Calderhead, D., Perry Fell, H., & Strober, W. (1995). Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity,2(5), 507-521. Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., … & Okumura, K. (1999). CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. The Journal of Immunology, 162(12), 7058-7066. Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., & Fell, H. P. (1993). Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions. The Journal of Immunology,151(10), 5261-5271. |