Anti-Mouse CD180 (RP-105) SAFIRE Purified
The RP/14 monoclonal antibody binds to mouse CD180, a 105kDA cell surface molecule consisting of extracellular leucine rich repeats (LCC) and a short cytoplasmic tail also known as Bgp-95 and RP105. CD180 is expressed on B cells, dendritic cells, monocytes, and macrophages. It forms a cell surface receptor complex with MD-1 and with TLR4 is involved with the recognition of bacterial lipopolysaccharide (LPS). LDN-214119
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Clone
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RP/14
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Mouse
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Isotype:
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Rat IgG2a, kappa
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| Research Interest: | , |
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Miyake, K., Shimazu, R., Kondo, J., Niki, T., Akashi, S., Ogata, H., … & Kimoto, M. (1998). Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. The Journal of Immunology,161(3), 1348-1353. Miyake, K., Yamashita, Y., Ogata, M., Sudo, T., & Kimoto, M. (1995). RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. The Journal of Immunology, 154(7), 3333-3340. Chan, V. W., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., … & Tarakhovsky, A. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. The Journal of experimental medicine,188(1), 93-101. |