Anti-Mouse CD152 (CTLA-4) Purified
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator.
The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
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Clone
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UC10-4F10-11
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Format: |
Purified
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., & Thompson, C. B. (1996). Regulation of surface and intracellular expression of CTLA4 on mouse T cells. The Journal of Immunology, 157(11), 4762-4770. Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., … & Bluestone, J. A. (1994). CTLA-4 can function as a negative regulator of T cell activation. Immunity, 1(5), 405-413. Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., & Holmberg, D. (1998). Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of Thymocytes. The Journal of experimental medicine, 188(7), 1239-1246. |