Anti-Mouse CD140b (PDGF Receptor b) SAFIRE Purified
The APB5 monoclonal antibody specifically binds to the mouse CD140b molecule, otherwise known as the Platelet-Derived Growth Factor (PDGF) Receptor beta chain. CD140b is a receptor tyrosine kinase expressed on embryonic tissue and adult mesenchymal-derived cells. The APB5 antibody is reported to block the binding of PDGF-BB to the PDGF receptor. LY2606370
|
Clone
|
APB5
|
|
Format: |
SAFIRE Purified
|
|
Applications
|
FC, FA
|
|
Reactivity
|
Mouse
|
|
Isotype:
|
Rat IgG2a, kappa
|
| Research Interest: | |
| Cell Type: | |
|
Preperation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Jo, N., Mailhos, C., Ju, M., Cheung, E., Bradley, J., Nishijima, K., … & Shima, D. T. (2006). Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. The American journal of pathology,168(6), 2036-2053. Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., … & Kita, T. (2001). Functional blockade of platelet-derived growth factor receptor-β but not of receptor-α prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E–deficient mice. Circulation, 103(24), 2955-2960. Soriano, P. (1994). Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes & development, 8(16), 1888-1896. |