Anti-Mouse CD103 (Integrin alpha E) SAFIRE Purified
The 2E7 monoclonal antibody specifically reacts with mouse CD103, a type I transmembrane glycoprotein in the integrin family that bind to E-cadherin. CD103 is expressed on intraepithelial lymphocyte T cells, peripheral regulatory T cells, lamina propria T cells, and a subset of dendritic cells. It is reported to be involved in T cell homing and immune system regulation. GDC-0835
|
Clone
|
2E7
|
|
Format: |
SAFIRE Purified
|
|
Applications
|
FC, FA
|
|
Reactivity
|
Mouse
|
|
Isotype:
|
Armenian Hamster IgG
|
| Research Interest: | |
| Cell Type: | , , |
|
Preperation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Hadley, G. A., Bartlett, S. T., Via, C. S., Rostapshova, E. A., & Moainie, S. (1997). The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL. The Journal of Immunology, 159(8), 3748-3756. Schön, M. P., Schön, M., Parker, C. M., & Williams, I. R. (2002). Dendritic Epidermal T Cells (DETC) are Diminished in Integrin &agr; E (CD103)-Deficient Mice. Journal of investigative dermatology, 119(1), 190-193. Zikri, N. N., Schumer, E., Wang, J. J., Gaughan, A., Hadley, G. A., & Moffatt-Bruce, S. D. (2010). Induction of CD4< sup>+</sup> CD25< sup>+</sup> T Regulatory Cells with CD103 Depletion. Journal of Surgical Research, 163(1), 162-168. |