Anti-Human TIM3 APC
The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection. GK922
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Clone
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F38-2E2
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Format: |
APC
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | |
| Cell Type: | Th1 cells, , , Th17 cells |
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Klibi, J., Niki, T., Riedel, A., Pioche-Durieu, C., Souquere, S., Rubinstein, E., … & Busson, P. (2009). Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells. Blood, 113(9), 1957-1966. Hastings, W. D., Anderson, D. E., Kassam, N., Koguchi, K., Greenfield, E. A., Kent, S. C., … & Kuchroo, V. K. (2009). TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European journal of immunology, 39(9), 2492-2501. Koguchi, K., Anderson, D. E., Yang, L., OConnor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006). Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of experimental medicine, 203(6), 1413-1418. |