Anti-Human/Mouse OCT3/4 PE
The EM92 monoclonal antibody reacts with human and mouse Oct 3/4, a POU family transcription factor. Oct 3/4 is encoded by the Pou5F1 gene and expressed on undifferentiated cells and lost in adult tissue. Fbx15, FGF-4, NANOG, Rex1, and UTF1 expression is regulated with Oct 3/4 and in many cases gene expression is regulated in concert with Sox2. BMN-675
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Clone
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EM92
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Format: |
PE
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Rat IgG2a, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. cell, 131(5), 861-872. Niwa, H., Miyazaki, J. I., & Smith, A. G. (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature genetics, 24(4), 372-376. Okamoto, K., Okazawa, H., Okuda, A., Sakai, M., Muramatsu, M., & Hamada, H. (1990). A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell, 60(3), 461-472. |