Anti-Human/Mouse CD27 SAFIRE Purified
The LG.3A10 monoclonal antibody binds to CD27, 45kDA molecule in the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on memory B cells, NK cells, mature T cells, and a subset of thymocytes. Cd27 is involved in the interactions between B and T cells through its ligand CD70. The LG.3A10 antibody is cross-reactive with human, mouse and rat CD27. TG6-10-1
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Clone
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LG.3A10
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human, Mouse, Rat
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Hendriks, J., Xiao, Y., & Borst, J. (2003). CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. The Journal of experimental medicine, 198(9), 1369-1380. Sakanishi, T., & Yagita, H. (2010). Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.Biochemical and biophysical research communications, 393(4), 829-835. Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., & Borst, J. (1995). Novel mAbs reveal potent co-stimulatory activity of murine CD27. International immunology, 7(4), 551-557. |