Anti-Human CD66b Purified


The G10F5 monoclonal antibody specifically reacts with human CD66b, a 100kDa glycosylphosphatidylinositol (GPI) linked protein in the granulocyte-specific activation family. CD66b is expressed on granulocytes, neutrophils, and eosinophils. It is reported that this molecule plays a role in regulating neutrophil activation and cellular adhesion. It was previously classified as CD67, but renamed CD66b in the Fifth HLDA Workshop. ABT-201

Clone
G10F5
Format:
Purified
Applications
FC, IHC
Reactivity
Human
Isotype:
Mouse IgM, kappa
Research Interest:
Cell Type:
Preperation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Lund-Johansen, F. R. I. D. T. J. O. F., Olweus, J. O. H. A. N. N. A., Horejsi, V. A. C. L. A. V., Skubitz, K. M., Thompson, J. S., Vilella, R., & Symington, F. W. (1992). Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65). The Journal of Immunology148(10), 3221-3229.

Schmidt, T., Zündorf, J., Grüger, T., Brandenburg, K., Reiners, A. L., Zinserling, J., & Schnitzler, N. (2012). CD66b overexpression and homotypic aggregation of human peripheral blood neutrophils after activation by a gram-positive stimulus. Journal of leukocyte biology91(5), 791-802.

MED: 19053869

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