Anti-Human CD64 (Fc gamma Receptor 1) SAFIRE Purified
The 10.1 monoclonal antibody specifically reacts with human CD64, a 75kDA type I transmembrane glycoprotein that is the high affinity receptor for IgG. CD64 is expressed on macrophages and dendritic cells and is involved in antibody-dependent cellular toxicity, cytokine release phagocytosis, and endocytosis. The 10.1 antibody is reported to recognize the EC3 epitope of CD64. Pacritinib
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Clone
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10.1
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Format: |
SAFIRE Purified
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Applications
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FC, FA, IHC
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press. Dougherty, G. J., Selvendran, Y., Murdoch, S., Palmer, D. G., & Hogg, N. (1987). The human mononuclear phagocyte high‐affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1. European journal of immunology,17(10), 1453-1459. Indik, Z. K., Hunter, S., Huang, M. M., Pan, X. Q., Chien, P., Kelly, C., … & Schreiber, A. D. (1994). The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI. Experimental hematology, 22(7), 599-606. |