Anti-Human CD2 SAFIRE Purified
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates.. RVX-208
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Clone
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RPA-2.10
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Hahn, W. C., Burakoff, S. J., & Bierer, B. E. (1993). Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology, 150(7), 2607-2619. Aversa, G. G., Bishop, G. A., Suranyi, M. G., & Hall, B. M. (1987, February). RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. In Transplantation proceedings (Vol. 19, No. 1 Pt 1, pp. 277-278). |