Anti-Human CD289 (TLR9) PE
The 72-1665 monoclonal antibody specifically reacts with CD289, also known as human toll-like receptor 9 (TLR9). CD289 is involved in the activation of innate immunity, in acquired immune responses, and autoimmune diseases. It is involved in the immune system’s response to unmethylated CpG dinucleotide sequences such as those found in bacterial, viral, or synthetic DNA. CD289 assists in pathogen recognition and is expressed by subtypes of dendritic cells and B cells. OTX-016
|
Clone
|
72-1665
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
Rat IgG2a, kappa
|
| Research Interest: | |
| Cell Type: | , |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., … & Golenbock, D. T. (2004). TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nature immunology, 5(2), 190-198. Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C., Kruhlak, M. J., & Segal, D. M. (2004). TLR9 is localized in the endoplasmic reticulum prior to stimulation.The Journal of Immunology, 173(2), 1179-1183. József, L., Khreiss, T., El Kebir, D., & Filep, J. G. (2006). Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. The Journal of immunology, 176(2), 1195-1202. |