Anti-Human CD282 (TLR2) PE
The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2). It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on peripheral blood monocytes and is involved distinguishing bacterial lipoproteins. The TL2.1 antibody blocks the receptor and immunoprecipitates TLR2 from human mammary epithelial cells (HMEC) and peripheral blood mononuclear cells (PBMC). AZD9497
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Clone
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TL2.1
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG2a, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Flo, T. H., Halaas, Ø., Lien, E., Ryan, L., Teti, G., Golenbock, D. T., … & Espevik, T. (2000). Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.The Journal of Immunology, 164(4), 2064-2069. Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., … & Golenbock, D. T. (1999). Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. Journal of Biological Chemistry, 274(47), 33419-33425. Cook, E. B., Stahl, J. L., Esnault, S., Barney, N. P., & Graziano, F. M. (2005). Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for< i> Staphylococcus aureus</i> involvement in chronic ocular proinflammatory responses. Annals of Allergy, Asthma & Immunology, 94(4), 486-497. |