Anti-Human CD27 SAFIRE Purified
The LG.7F9 monoclonal antibody binds to CD27, 45kDA molecule in the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on memory B cells, NK cells, mature T cells, and a subset of thymocytes. Cd27 is involved in the interactions between B and T cells through its ligand CD70. The LG.7F9 antibody is cross-reactive human, mouse, and rat CD27. PCI-32765
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Clone
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LG.7F9
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human, Mouse, Rat
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Tesselaar, K., Xiao, Y., Arens, R., van Schijndel, G. M., Schuurhuis, D. H., Mebius, R. E., … & van Lier, R. A. (2003). Expression of the murine CD27 ligand CD70 in vitro and in vivo. The journal of immunology, 170(1), 33-40. Lee, E. M., Hurh, S., Cho, B., Oh, K. H., Kim, S. U., Surh, C. D., … & Ahn, C. (2013). CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T cell death. Stem cell research & therapy, 4(3), 56. Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., & Borst, J. (1995). Novel mAbs reveal potent co-stimulatory activity of murine CD27. International immunology, 7(4), 551-557. |