Anti-Human CD279 (PD-1) SAFIRE Purified
The J116 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The lack or mutation of CD279 is linked to autoimmune disorders.The J116 antibody does not block the binding of the PD-1 ligand, but does inhibit the PD-1 signal transduction. (-)-DHMEQ
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Clone
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J116
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Format: |
SAFIRE Purified
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Applications
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FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Ramsay, A. G., Clear, A. J., Fatah, R., & Gribben, J. G. (2012). Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood,120(7), 1412-1421. Xiao, W., Jiang, L. F., Deng, X. Z., Zhu, D. Y., Pei, J. P., Xu, M. L., … & Yue, M. (2015). PD-1/PD-L1 signal pathway participates in HCV F protein-induced T cell dysfunction in chronic HCV infection. Immunologic research, 1-12. Taglauer, E. S., Trikhacheva, A. S., Slusser, J. G., & Petroff, M. G. (2008). Expression and function of PDCD1 at the human maternal-fetal interface.Biology of reproduction, 79(3), 562-569. Jurado, J. O., Alvarez, I. B., Pasquinelli, V., Martínez, G. J., Quiroga, M. F., Abbate, E., … & García, V. E. (2008). Programmed death (PD)-1: PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis. The Journal of Immunology, 181(1), 116-125. |