Anti-Human CD278 (ICOS) PE-Cyanine7
The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells. GM6002
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Clone
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ISA-3
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Format: |
PE-Cyanine7
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999). ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature, 402, 21-24. Quiroga, M. F., Pasquinelli, V., Martínez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., … & García, V. E. (2006). Inducible costimulator: a modulator of IFN-γ production in human tuberculosis. The Journal of Immunology, 176(10), 5965-5974. Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., … & Dianzani, U. (2000). The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical. European journal of immunology,30(12), 3463-3467. |