Anti-Human CD16 SAFIRE Purified
The CB15 monoclonal antibody specifically binds to human CD16, a low affinity Fc receptor. It is expressed on NK, neutrophils, macrophages, monocytes, and placental trophoblasts. CD16 is expressed in CD16a and CD16b forms. CD16a is a polyeptide anchored transmembrane protein and CD16b is a monomeric glycosylphosphatidylinositol (GPI)-anchored protein found in neutrophils. CD16 is reported to be involved in NK cell activation and signal transduction. BMN-673
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Clone
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CB16
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Wirthmueller, U., Kurosaki, T., Murakami, M. S., & Ravetch, J. V. (1992). Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain. The Journal of experimental medicine, 175(5), 1381-1390. Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., … & Malavasi, F. (2002). Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells. Blood, 99(7), 2490-2498. Araya, N., Takahashi, K., Sato, T., Nakamura, T., Sawa, C., Hasegawa, D., … & Yamano, Y. (2011). Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease.Antiviral therapy, 16(1), 89. |