Animal-Free Recombinant Human FGF-basic (154 a.a.)
FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 95% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Cow, Dog, Frog, Hamster, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Human + Mouse, Rat + Chicken
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Biological Activity
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Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 u
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AA Sequence
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AAGSITTLP ALPEDGGSG AFPPGHFKD PKRLYCKNG GFFLRIHPD GRVDGVREK SDPHIKLQL QAEERGVVS IKGVCANRY LAMKEDGRL LASKCVTDE CFFFERLES NNYNTYRSR KYTSWYVAL KRTGQYKLG SKTGPGQKA ILFLPMSAK S
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| Research Interest: | , , , , Inflammation, Proliferation and Cell Cycle |
| Cell Type: | , , Endothelial Cells, Neurons |
| Protein Cross Reactivity: | Cow, Dog, Frog, Hamster, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Human + Mouse, Rat + Chicken |