Animal-Free Recombinant Human FGF-8
FGF-8 (FGF-8b) is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF8 A and B are identical unlike human and mouse FGF8 E and F are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant human FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues. Manufactured using all non-animal reagents.
|
Source: |
E. Coli
|
|   | |
|
Purity:
|
Above 95% as determined by SDS-PAGE Analysis.
|
|   | |
|
Cross Reactivity: |
Chicken, Mouse, Rabbit, Rat
|
|   | |
|
Biological Activity
|
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF- receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
|
|   | |
|
AA Sequence
|
MQVTVQSSP NFTQHVREQ SLVTDQLSR RLIRTYQLY SRTSGKHVQ VLANKRINA MAEDGDPFA KLIVETDTF GSRVRVRGA ETGLYICMN KKGKLIAKS NGKGKDCVF TEIVLENNY TALQNAKYE GWYMAFTRK GRPRKGSKT RQHQREVHF MKRLPRGHH TTEQSLRFE FLNYPPFTR SLRGSQRTW APEPR
|
| Research Interest: | , , , , Proliferation and Cell Cycle |
| Cell Type: | |
| Protein Cross Reactivity: | Chicken, Mouse, Rabbit, Rat |