3-Deazaneplanocin A
3-Deazaneplanocin A is an epigenetic modifier, inhibiting histone h3 lysine 27. The mechanism for this action is the inhibition of lysine methyltransferases, especially EZH2. It is reported to induce apoptosis in cancer cells to the exclusion of normal cells and useful in the generation of chemically induced pluripotent stem cells (CiPSCs). Silvestrol
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Applications
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FA
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Synonyms:
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DZNep, NSC 617989
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Formulation:
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Crystalline solid
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Chemical Name:
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(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
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Molecular Formula:
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C12H14N4O3 |
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Molecular Weight:
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262.3
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CAS Number
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102052-95-9
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Purity:
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≥97%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., … & Bhalla, K. N. (2009). Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood, 114(13), 2733-2743. Glazer, R. I., Hartman, K. D., Knode, M. C., Richard, M. M., Chiang, P. K., Tseng, C. K., & Marquez, V. E. (1986). 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochemical and biophysical research communications, 135(2), 688-694. Bray, M., Raymond, J. L., Geisbert, T., & Baker, R. O. (2002). 3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice. Antiviral research, 55(1), 151-159. |