1-Oleoyl Lysophosphatidic Acid (sodium salt)
1-Oleoyl Lysophosphatidic Acid is a lysophophatidic acid (LSA) with oleic acid in the sn-1 position that is an endogenous agonist for LPA1 and LPA2 receptors. It is reported to inhibit the differentiation of neural stem cells into neurons and is involved in multiple biological activities such as smooth muscle contraction, platelet aggregation, cell proliferation, cell migration, and calcium mobilization. 1-Oleoyl Lysophosphatidic Acid is commonly used for growth stimulation in a variety of cell lines. AP20187
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Applications
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FA
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Synonyms:
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9-Octadecenoicacid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 1-oleoyl sodium salt, LPA sodium salt
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Formulation:
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Crystalline solid
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Chemical Name:
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[2-hydroxy-3-(octadec-9-enoyloxy)propoxy]phosphonic acid sodium
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Molecular Formula:
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C21H40O7P Na |
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Molecular Weight:
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458.5
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CAS Number
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22556-62-3
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at-20°C.
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References:
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McIntyre, T. M., Pontsler, A. V., Silva, A. R., Hilaire, A. S., Xu, Y., Hinshaw, J. C., … & Prestwich, G. D. (2003). Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist.Proceedings of the National Academy of Sciences, 100(1), 131-136. Dottori, M., Leung, J., Turnley, A. M., & Pebay, A. (2008). Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells, 26(5), 1146-1154. Lapierre, D. M., Tanabe, N., Pereverzev, A., Spencer, M., Shugg, R. P., Dixon, S. J., & Sims, S. M. (2010). Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. Journal of Biological Chemistry, 285(33), 25792-25801. |